[6][8] Byzantine emperor and founder of the Macedonian dynasty, Basil I, was born to a peasant family in Chariopolis, possibly in 811.

In the 11th century, a bishop Michael is known through his seal; from the decoration it appears that he may have previously been a member of the clergy of the Hagia Sophia in Constantinople.

[5][6] In the aftermath of the battle, Chariopolis and other nearby towns were conquered by the Bulgarians under Tsar Kaloyan; a large part of the population was forcibly deported and resettled along the Danube.

[6] In 1305 or 1306, an unnamed bishop of Chariopolis attended a synod called by Patriarch Athanasius I of Constantinople to condemn John Drimys.

After Kantakouzenos' abdication in 1354, Süleyman conquered many cities "up to Chariopolis", establishing the first Ottoman province on European soil.

[12] The traveller Evliya Çelebi visited the town in the mid-17th century, describing it as prosperous, a "little Edirne", [[1]] or Adrianopolis with much water and beautiful gardens.