[5][3] The three genomic RNA segments are encapsidated by copies of the N protein in the form of ribonucleoprotein (RNP) complexes.
The tick is commonly found on an alpine vole inhabiting the Hazara District of Pakistan.
[4] Diagnosis in rodents is made by detecting Hazara orthonairovirus antibodies in the serum.
[3] Hazara virus is in the same Nairovirus serogroup as Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV), and has similar disease progression to that seen in Crimean-Congo Hemorrhagic Fever (CCHF) infections in suckling mice and in the interferon receptor knockout mouse model [10][4] This indicates that Hazara orthonairovirus could represent a valid model for CCHFV infection.
While CCHFV is the most important human pathogen in this serogroup, Hazara research is potentially useful in the development of antiviral medications for all viruses in the genus Nairovirus.