Upon release, He Fucked the Girl out of Me received praise and discussion from reviewers, who resonated with the game's personal themes and the mature handling of its subject matter.

He Fucked the Girl Out of Me is an interactive fiction game that narrates a linear set of scenes depicting the memories of the player character.

Ann is a transgender woman who is struggling financially as a college student as they attempt to fund a prescription of estradiol that is not subsidized under the Affordable Care Act.

Re-reading her diary entries from that time, Ann encounters the line "He fucked the girl out of me", reflecting that the experience degraded her, made her hate herself and her feminine identity, and led her to see self-worth and value only in terms of sex.

In an epilogue set years after the events of the incident, Ann examines objects in a box, including clothes from her time doing sex work, and throws them away.

[12][13] Sisi Jiang of Kotaku described the game as being about "all the ways in which American society fails its most vulnerable", finding it to be "terrifying because of its mundanity".

[7] Smangaliso Simelane of Destructoid considered the game's narrative was "profoundly personal" and "uncomfortably invasive", finding its "freedom to breach topics and express viewpoints seldom interrogated by the mainstream", including sex work, shame and trauma.

[19][20] The game appeared at the International Documentary Film Festival Amsterdam 2022,[2] where it received the DFA DocLab Award for Digital Storytelling and assessed as "a unique approach to conveying a complicated personal history in the artist's own terms".