[1] As a commander of a cavalry force under Zhang Xueliang, he escaped assassination by KMT radicals during the Xi'an Incident by the help of Yang Hucheng.

[2][3] In the People's Republic of China, he is celebrated by the Revolutionary Committee of the Kuomintang for his participation in the Second United Front between the KMT and the Chinese Communist Party against Japanese invaders during the Second Sino-Japanese War.

After graduating from the country in the autumn of 1919, he served as the tactical instructor and squad leader of the cavalry section of the Baoding Military Academy.

After Fengtian Clique won the Second Zhili-Fengtian War, Zhang Zuolin led the Xuanfu Army south to expand territory.

Jiang Dengxuan and Han Linchun convinced He Zhuguo to abandon plans to study in Japan, and appointed him the Xuanfu Army combat section chief of staff.

The Xuanfu Army advanced all the way to Bengbu, Anhui, But within half a year, the communication lines were intercepted by Sun Chuanfang and Chen Tiaoyuan, and Feng Jun was forced to withdraw to the northeast.

In 1927, He Zhuguo entered Henan with Zhang Xueliang's regiment to fight against the Wu Peifu's former deputy commander, Jin Yun'e.

He Zhuguo served as the lieutenant general of the 3rd Brigade of the Northeast Army Infantry, stationed in Rehe Lingyuan.

After the September 18th Incident in 1931, Zhang Xueliang, who presided over the Beiping Branch of the National Government Military Commission, again ordered He Zhuguo to station in Shanhaiguan.

At the end of November 1932, Masjiro Ochiai asked He Zhuguo to create an independent buffer zone in Luandong and Rehe, promising to supply all governmental and military expenses.

Because of the weak resistance of Chinese defenders such as Zhang Zuoxiang, Wan Fulin, and Tang Yulin, the Japanese army occupied Rehe.

In January 1934, Zhang Xueliang was recalled by Chiang Kai-shek and served as deputy commander-in-chief of the Yu-E-Wan anti-communist encirclement campaign.

In July of the same year, He Zhuguo was instructed to leave the army and study in the Lushan Officer Training Corps.

In January 1935, Chiang Kai-shek changed the headquarters of the bandits from Henan, Hubei and Anhui to Wuchang, the chairman of the military committee of the National Government, and Zhang Xueliang served as the director of the camp.

On February 2, the young main officer of the Northeastern Army killed Wang Yizhe, and He Zhuguo fled into Yanghucheng Mansion because of news.

At that time, He Zhuguo, who was stationed in Xianyang, was instructed to go to the northern plains of Jinbei to stand by and was included in the second theater sequence.

Soon after, the main force of the Japanese army went south through Shuoxian County, and the Ministry of He Zhu moved to the west of Jingping for rest.

In the winter of 1938, the Japanese army attacked Ikzhao League from Chahar, and the National Government decided to relocate the Mausoleum of Genghis Khan.

In July of the same year, the tomb of Genghis Khan moved to the Taibai Palace in Xinglong Mountain, Gansu.

During his stay in northern Shaanxi, He Zhuguo went to Yan'an three times to solve military problems and was welcomed by Mao Zedong.

Soon, the New Fourth Army Peng Xuefeng guerrilla detachment entered Boxian, Huaiyang, and defended with He Zhu ’s Ministry.

Tan Youlin, deputy brigade commander of the New Fourth Army, etc., went to Yan'an to attend the 7th National Congress of the Chinese Communist Party.

There are a large number of puppet troops in Shangqiu, Henan and Bo County in the north of Anhui, around the defense zone of Hezhu State Department.

In January 1941, with the cooperation of a large number of armored vehicles, the Japanese army stationed in Shangqiu set off for Guide and went to the front of the boundary to sweep the Huangfan area.

In fact, Tang Enbei was ordered by Chiang Kai-shek to monitor the Chinese Communist Party and the New Fourth Army.

Because He Zhuguo had cooperated with the 120th Division of the Eighth Route Army in northern Shanxi and had frequent contacts with Yan'an, Tang Enbo was wary of He Zhu's state.

Chiang Kai-shek persuaded him: "First solve the Northeast military problem, it will take about two years, then go to govern the Yellow River!"

After the victory of China's Anti-Japanese War, he served as chief of staff of the Northeast Xingyuan, but failed to take office because of sudden blindness in both eyes.

[citation needed] In the anti-rightist movement in 1957, He Zhuguo was labeled as a "rightist" because he proposed two opinions to the Chinese Communist Party.

On September 15, the CPPCC National Committee held a farewell ceremony for Comrade He Zhuguo's body in Beijing.