It starred the original casts of Healing Hands: Lawrence Ng and Bowie Lam; and Healing Hands II: Moses Chan, Maggie Shiu and Raymond Cho along with new additions to the series, Melissa Ng, Bernice Liu and Gigi Lai.

The storyline begins with the end of the SARS epidemic in Hong Kong and the accidental death of Paul's (Lawrence Ng) ex-girlfriend Tracy (Yoyo Mung).

Lawrence life begins to be heading into a tailspin after failing to save an Ho Tak-kwong's (Kenny Wong) baby, but Frances (Gigi Lai) is always there to support him.

Henry (Bowie Lam) appears at the beginning with a new girlfriend, having broken up with Annie (Flora Chan) between Healing Hands 2 and 3.

The drama follows the challenges that the characters face- including the medical obstacles faced by the doctors of Yan Oi hospital and the love life troubles that the various couples of the series overcome.