[1] This bureau was newly established under the re-organization of policy bureaux proposed by Carrie Lam, the fifth Chief Executive of Hong Kong, and was adopted by John Lee, the succeeding Chief Executive after Carrie Lam.

[2] On 19 June 2022, the Central People's Government announced the appointment of Professor Lo Chung-mau, previously the Head of University of Hong Kong-Shenzhen Hospital, as the first Secretary for Health.

[4] There is only one department under the Health Bureau:[5] The CHP was created in 2003 in response to the SARS outbreak and copies the function of the CDC in the United States.

[6] In October 2022, the Health Bureau was reported to be in discussions with the Hong Kong Monetary Authority to finalize details for the Global Financial Leaders' Investment Summit in November 2022, where the Health Bureau was discussing an option for COVID-19 positive guests to leave Hong Kong if leaving on private jets, but would not be allowed to leave on commercial airlines.

[8] In May 2023, after some Hongkongers expressed reluctance to have organ donations go to mainland China, the Health Bureau said "Some individuals also wantonly vilify the constructive significance of the proposed establishment of a standing mutual assistance mechanism for transplant by the two places, undoubtedly despising the inseparable ties between citizens of Hong Kong and the Mainland.