The Health and Safety Commission (HSC) was a United Kingdom non-departmental public body.

The Commission's duties were to:[3] The Commission was further obliged keep the Secretary of State informed of its plans and ensure alignment with the policies of the Secretary of State, giving effect to any directions given to it.

[5] On 1 April 2006, the Commission ceased to have responsibility for railway safety.

[9] In August 2007, the Department for Work and Pensions started consultation on merger of the HSC and HSE to a largely positive response.

[10] On 18 March 2008, government minister Lord McKenzie of Luton announced that the merger would be completed during spring 2008.