In 1997, the Clarksville Coyotes, Tennessee Tomahawks, and Columbia Mules joined the league from the Big South League.

The league fielded six teams in 1998, but teams in Huntington, West Virginia, and Booneville, Mississippi, suspended operations midway through the season and the league suspended operations after the Cook County Cheetahs jumped to the Frontier League.

The Mid-America League was based in Lafayette, Indiana, and was an independent baseball league located entirely within Indiana.

[1] The Mid-America League operated in only four cities that were not served by Major or Minor League Baseball teams, and is not affiliated with either.

This article related to a baseball league, competition or tournament is a stub.