The story is based on the graphic novel, The Melting Pot, written by Kevin Eastman, Simon Bisley and Eric Talbot.

The key to the chamber, a glowing green crystal (resembling the "Loc-Nar" in Heavy Metal) that can lead the bearer back to the fountain and drives anyone who possessed it insane, was cast into space and lost among the stars.

At a renegade space station, where a sex robot distracts Germain, Julie finds Tyler in a nightclub and critically injures him.

Julie wakes up on Uroboris, a desert planet, and meets Odin, a mysterious cloaked sage, and his assistant, Zeek, a rock-like creature who appeared when Tyler found the crystal.

While exploring the planet, he finds a race of reptilian beings and conquers them by defeating their champion and their leader in a death match.

At the citadel, Julie undergoes a bath ritual where armor of scanty clothing, like Taarna's in Heavy Metal, is bestowed upon her.

In the fighting, Lambert suffers a near-fatal injury and grabs for Tyler's last vial of immortality serum, accidentally breaking it on the ground.

However, Zeek, who befriended Julie, pulls the crystal key from the pedestal, locking Odin inside the fountain chamber forever, and flies into outer space.

During 2008[7][8] and into 2009,[9] reports circulated that David Fincher and James Cameron would executive produce, and each direct one of the eight to nine segments for a new film based on Heavy Metal.

However, Paramount Pictures decided to stop funding the film by August 2009[10] and no distributor or production company has shown interest in the second sequel since.

[12] However, on March 11, 2014, with the formation of his very own television network, El Rey, Rodriguez considered switching gears and bringing it to TV.

[13] Fincher and Miller subsequently developed their plans into Love, Death & Robots, an original animated series for Netflix initially released in 2019.

In his AllMusic review, Greg Prato said that the album was a "truer heavy metal soundtrack" than that of the first film, featuring a combination of established bands such as Pantera, Monster Magnet, and Machine Head; then-newer bands such as Queens of the Stone Age, System of a Down, Hate Dept., Puya, and Coal Chamber; and a few non-metal artists such as Billy Idol, Insane Clown Posse, Twiztid, and Bauhaus.