Hedwig of Schleswig-Holstein (15 July 1626 – 5 October 1678) was the daughter of king Christian IV of Denmark and Kirsten Munk.

As with her siblings, she was raised by her grandmother Ellen Marsvin and the royal governess Karen Sehested.

She and her twin sister, Christiane, were both married in Copenhagen royal palace in 1642: she to the noble Ebbe Ulfeldt.

In 1652, her spouse was deposed from his position on Bornholm, and the couple left for the Swedish court.

The marriage was unhappy: Ulfeldt abused her - she called him "the damned creature" - and she had an affair with his servant.