Heinrich XXII, Prince Reuss of Greiz (28 March 1846 – 19 April 1902) was the reigning sovereign of Reuss-Greiz, a small principality of the German states, from 1859 until his death in 1902.

Like his parents, Heinrich remained anti-Prussian his entire life, repeatedly rejecting Prussian measures such as Kulturkampf and the creation of civil marriages.

Heinrich, as well as his subjects in Reuss, refused fully to accept that the Hohenzollern German Emperors had precedence over other royal houses.

[3][4] In the late 1840s, there were discussions at the Frankfurt National Assembly for the creation of a hereditary imperial royal family that would rule over a united Germany, along with a new parliament and constitution.

[5] In the end, Heinrich's distant cousin Prince Heinrich XXVII of Reuss zu Schleiz was chosen; his wife, Princess Elise of Hohenlohe-Langenburg was a cousin of both Kaiser and his wife Empress Augusta Viktoria, and the prince himself had served alongside Emperor Wilhelm in the regiment of the Hussars of the Guard, thus repairing relations between the houses of Hohenzollern and Reuss.