[8] After graduating from Oxford,[9] Lewis gained a post-graduate diploma in newspaper journalism from London's City University.

[citation needed] Subsequently, she was accepted on the Daily Mail's programme for trainee sub-editors, working in the job for a few years, and later joining the team responsible for commissioning features for the newspaper.

[30][31][32] Since June 2023, Helen Lewis has been presenting Page 94: The Private Eye Podcast, with Ian Hislop, Andrew Hunter Murray, and Adam Macqueen, which covers current affairs and investigative journalism with a satirical slant.

In the introduction, she wrote: "For anyone interested in equality, it should be obvious that trans people are subject to harassment simply for the way they express their gender identity.

[38] In November 2020, due to her statements, game developer Ubisoft removed from Watch Dogs: Legion two in-game political podcasts featuring Lewis's voice.