She was born in Burlington, Vermont, and grew up from the age of ten in Rochester, New York.
[2] Her mature style is very similar to his, with less detail and finer color,[2] and contemporary reports noted that she was almost his equal as a master painter.
[3] Her shows during this time, for example at the Düsseldorf art dealers Bismeyer & Kraus in March 1870, were highly praised in the press.
[6] She had major commissions and exhibitions throughout Germany, at the Paris Salon, and at the National Academy of Design in New York.
While living in Düsseldorf, Searle had met a widowed American painter, James William Pattison (1844–1915); in 1876 they married.