Helena Asanina Kantakouzene (died after 1394) was regent of the Lordship of Salona in Frankish Greece from 1382 until its conquest by the Ottoman Empire in 1394 on behalf of her daughter Maria Fadrique.
She was known to be living with her mother and sister Maria in Gratianopolis (modern Gratini), when Emperor John V Palaiologos moved the women to Tenedos.
In April 1388, King John I of Aragon offered her the rights of castellan over Athens on the condition she would defend the city.
This arrangement came close to being consummated with a marriage, for King Peter IV of Aragon wrote to Helena on 17 August 1386 and reproached her for marrying her daughter to a foreigner.
Nerio Acciaioli is said to have sought her hand for his brother-in-law Pietro Saraceno, but in 1390 arrangements appear to have been made for Maria to marry Matthew of Moncada, son of William Raymond of Montcada, Count of Augusta.