[2] Many of her projects championed international contemporary art with a special emphasis on photography, video and installation, at a time when these mediums were practically unknown in Spain.

[3] The gallery has presented works from artists including Angela Bulloch,[4] Thomas Demand,[4] Elmgreen & Dragset[5] Axel Hütte,[6] Isaac Julien,[6] Imi Knoebel,[6] Karin Sander[6] and Santiago Sierra.

The first phase of the Fundación Helga de Alvear Visual Arts Centre, based in an early 20th-century building known as Casa Grande, opened in the historic quarter of Cáceres in 2010.

[8] As of 2021, the Museum presents a selection of around 200 works, around 5% of de Alvear's collection, including paintings, sculptures, photographs, video art, drawings and installations by more than 500 international artists.

[8] The semi-permanent exhibition allows the public to explore works by Josef Albers, Joseph Beuys, Dan Flavin, Nan Goldin, Jenny Holzer, Anish Kapoor, Paul Klee, Gordon Matta-Clark and Philippe Parreno.

[8] It also houses artworks by Louise Bourgeois, Kandinsky, Carmen Laffón, Robert Motherwell, Picasso, Tàpies, and Ai Weiwei, among others.

In addition, the museum has an outdoor garden featuring a sculpture of a hundred-year-old olive tree by Ugo Rondinone, and is connected to the facilities of the former Helga de Alvear Visual Arts Centre in the refurbished Casa Grande.

The funds were directed toward scientific work conducted by Luis Enjuanes, a virologist for the Spanish National Research Council (CSIC).