[1] Helicobacter pylori is by far the best known Helicobacter species, primarily because humans infected with it may develop gastrointestinal tract diseases such as stomach inflammation, stomach ulcers, duodenal ulcers, stomach cancers of the nonlymphoma type, and various subtypes of extranodal marginal zone lymphomass, e.g. those of the stomach, small intestines, large intestines, and rectumn.

H. pylori is also associated with the development of bile duct cancer and has been associated with a wide range of other diseases although its role in the development of many of these other diseases requires further study.

[citation needed] Helicobacter bizzozeronii bacteria are detected in the stomachs of their natural hosts - cats, dogs, foxes, and lynxes, as well as in the saliva of dogs.

Reports suggest that individuals, including children,[4] are infected with this bacterium by having close contact with these animals.

[3] It is important to diagnose H. bizzozeronii and the other H. heilmannii sensu lato infections in patients with the cited upper gastrointestinal tract diseases, including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g.amoxicillin, clarithromycin, plus a proton pump inhibitor[5] or metronidazole, clarithromycin, plus a proton pump inhibitor[3]) directed against the instigating bacterium.