According to Rob Zombie, there was not enough time to release advance copies to the press or create a music video for the first single, "What?

[8][9] British dark/horror/science fiction/steampunk artist Sam Shearon aka 'Mister Sam Shearon' (artwork for Godhead, Ministry, Slayer, IDW Publishing, Clive Barker, and tour merchandise for Iron Maiden and HIM[10]) also contributed to the artwork of Hellbilly Deluxe 2.

The first leg of the Hellbilly Deluxe 2 World Tour featured Nekromantix and Captain Clegg & The Night Creatures, the fictional band from Halloween II.

[9] Another new song, "Burn", was released on Rock Band on October 27 as part of a triple pack which also includes the hits "Dragula" and "Superbeast".

[13] The drummer on the studio recordings for Hellbilly Deluxe 2, Tommy Clufetos, left the band in early 2010 to play drums on Ozzy Osbourne's album Scream.

Clufetos was replaced by Murderdolls guitarist and Slipknot drummer Joey Jordison, initially as a touring member.

The intro to "Mars Needs Women" has been separated into the track "Theme for an Angry Red Planet".