He was born at Begowala, Sialkot where his father Dr Bhagat Singh Pruti worked in the Police and Jail Hospital at Gujranwala.
He studied locally and completed his MSc at the Government College in Lahore and joined Peterhouse, Cambridge, where he was a Charles Abercrombie Smith Student and obtained a Ph.D. in 1924.
He then joined the Indian Agricultural Research Institute and became the Imperial Entomologist, succeeding T.B.
He was a plant protection advisor to the Government of India and helped establish a locust warning system.
A number of genera of hemipterans have been named after him including Pruthiana, Pruthiorosius, and Pruthius.