In addition, oozing from mucocutaneous surfaces causing nosebleeds, blood-stained tears, and vicarious menstruation are common.

[4] Severe mental anxiety activates the sympathetic nervous system to invoke the fight-or-flight response to such a degree as to cause hemorrhage of the vessels supplying the sweat glands.

[8] Effects on the body include weakness and mild-to-moderate dehydration from the severe anxiety and both blood and sweat loss.

[9] The condition is very rare, but there are reports in the medical literature of successful treatment with beta blockers (propranolol 10 mg),[10][11] with significant reduction in the frequency of spontaneous blood oozing.

However, this etiology is not yet fully established, as the high prevalence of stress and anxiety in the modern era has not changed the incidence of this extremely rare disease, suggesting that other co-abnormalities also play a key role.