Industries in the vicinity of Hemlock Creek have largely consisted of mills and iron mines.
Hemlock Creek starts in Madison Township, a few miles north of the community of Columbia Hill.
It continues to parallel Pennsylvania Route 44 as it picks up its first tributary, West Hemlock Creek, and flows into Buckhorn.
It then flows southwest past Frosty Valley, where it picks up its second tributary, Frozen Run.
[4] Interstate 80 and Pennsylvania Route 44 are the main highways in the southern and western part of the watershed.
Much of the rock in the Hemlock Creek watershed is the Catskill Formation's Irish Valley Member and the Hamilton Group.
The Chenango-Pope-Holly soil series occurs in a small area in the southeast of the watershed, near Bloomsburg.
[4] A book from the 1800s described fossil ore, Bloomsburg red shale, and Middle Salina beds near Hemlock Creek.
[5] This ore contained hydrogen peroxide, silica, alumina, water, and traces of lime and carbonic acid.
[6] There is one anticlinal crest which starts north of Bloomsburg and ends near the valley of Hemlock Creek.
He arrived there in 1781 and owned a tract of land between the mouth of Hemlock Creek and Buckhorn.
[8] A mill was built on West Hemlock Creek for the purpose of producing boards and timber.
However, Barton had built a mill on the northern bank of Hemlock Creek 0.5 miles (0.80 km) from its mouth, shortly after arriving in the area.
[8] Another mill was built in the upper reaches of Hemlock Creek in 1812, by a man named Pepper.