Hemlock Run is a tributary of West Branch Fishing Creek in Sullivan County, Pennsylvania, in the United States.

Over the next several tenths of a mile, it gradually turns south and reaches its confluence with West Branch Fishing Creek.

[1] Hemlock Run joins West Branch Fishing Creek 9.73 miles (15.66 km) upstream of its mouth.

The first tributary is approximately 0.2 miles (0.32 km) long and joins Hemlock Run near its headwaters.

[2] The terminus of the glaciers during the late Wisconsinan period of glaciation was in the vicinity of Hemlock Run.

[2] A small portion of the valley of Hemlock Run is on bedrock consisting of sandstone and shale.

A resedimented glacial till known as the Wisconsinan Flow-Till also occurs near the stream in its lower reaches.

The Pennsylvania Game Commission has a permit to maintain the riprap and the streambed with the wingwalls.