Henderson Run is a 3.3 mi (5.3 km) long 1st order tributary to Pine Creek in Crawford County, Pennsylvania.

Henderson Run rises about 2 miles west of Dotyville, Pennsylvania in Crawford County and then flows south-southeast to Pine Creek about 1 mile northeast of East Titusville, Pennsylvania.

[2] Henderson Run drains 1.81 square miles (4.7 km2) of area, receives about 44.9 in/year of precipitation, and has a wetness index of 433.72 and is about 81% forested.

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