Hendrik Van Crombrugge started his career with Standard de Liège.

On 1 August 2019 it was announced that Van Crombrugge had signed a four-year contract at Anderlecht.

Van Crombrugge earned his first full international call-up when Roberto Martínez named him in the Belgium squad in September 2019.

[1] Van Crombrugge debuted with Belgium in a 1–1 friendly draw with Ivory Coast on 8 October 2020.

This biographical article related to association football in Belgium, about a goalkeeper, is a stub.