The primary 484-bed facility is on six city blocks across the street from U.S. Bank Stadium, with neighborhood clinics in the Minneapolis Whittier and East Lake neighborhoods, and the suburban communities of Brooklyn Center, Brooklyn Park, Golden Valley, St. Anthony and Richfield.

By the late 1960s, the hospital was a disorganized patchwork of buildings, leading to the decision to clear and rebuild the facility.

[3] The current hospital facility was completed in 1976 and renamed Hennepin County Medical Center, following a $25 million bond passed by voters in 1969.

[4] In 2015, the Hennepin County Board allocated $192 million for a new outpatient center which features multiple clinics across from the HCMC entrance.

[7] Hennepin Healthcare's East Lake Clinic in the historic Coliseum Building and Hall was among the property locations damaged by arson during the George Floyd protests in Minneapolis–Saint Paul.

[11] HCMC also provides emergency medical services (Hennepin EMS) for the cities of Minneapolis, Golden Valley, Shorewood, Eden Prairie, St. Louis Park, Hopkins, St. Anthony, Woodland, Excelsior, Deephaven, Tonka Bay, Richfield, and the majority of the city of Minnetonka.

All 911 response vehicles are equipped with handheld ultrasound, video laryngoscopes, LUCAS device and Zoll-X series cardiac monitors.