In 1965, it moved to its current location on Jackson St. and University Avenue and became St. Paul-Ramsey Hospital.

In 1977 the hospital's name became St. Paul-Ramsey Medical Center when the north section of the building is added to the Ramsey campus.

In early 2019 Regions Hospital started construction on a new 55 bed birth center, which opened in mid August 2020.

The new birth center features water birthing suites, expanded Level II NICU care in partnership with its partner facility Gilette Children's, and Minnesota's first enhanced couplet care rooms.

[4][5] In 2013, the cancer center received the "Three-Year with Commendation" and 2013 Outstanding Achievement awards from the American College of Surgeons.