Manguin entered the École des Beaux-Arts to study[1] under Gustave Moreau, as did Henri Matisse and Charles Camoin with whom he became close friends.

From 24 March to 30 April, the burgeoning of Fauvism was visible at the Indépendants, prior to the infamous Salon d'Automne exhibition of 1905 which historically marks the birth of the term Fauvism, after critic Louis Vauxcelles described their show of work with the phrase "Donatello chez les fauves" ("Donatello among the wild beasts"),[2] contrasting the paintings with a Renaissance-style sculpture that shared the room with them.

[3] At the 1905 Indépendants Manguin exhibited with Henri Matisse, Albert Marquet, Jean Puy, Othon Friesz, Raoul Dufy, Kees van Dongen, André Derain, Maurice de Vlaminck, Charles Camoin and Jean Metzinger.

[5] Matisse was in charge of the hanging committee, assisted by Manguin, Metzinger, Bonnard, Camoin, Laprade Luce, Marquet, Puy and Vallotton.

[5] In 1920, Manguin exhibited at the Gallery Marcel Bernheim together with Ottmann, Tirman, Alexandre-Paul Canu and others.