It sat at the far western edge of Anglo expansion in north-central Texas, but Native Americans remained a viable threat to current and future settlers.

By late 1862, Henrietta was abandoned, and white settlers returned east to Cooke and Montague counties.

[8] After heavy lobbying by businessmen, Henrietta became a logistical supply point for various operations in north-central Texas, including mining in Foard and Archer counties.

The St. Elmo Hotel, established about 1895 in Henrietta,[9] had among its guests Quanah Parker, who married two of his wives there, and U.S. President Theodore Roosevelt, when he toured the North Texas area.

The growth of Henrietta waned in the 20th century as Wichita Falls grew rapidly into the most prosperous economic center in the area.

In many ways, Henrietta is a "bedroom community" for Wichita Falls but is still the largest city in Clay County.

The play Texas presented during summers at the Palo Duro Canyon near Amarillo is loosely based on the history of Henrietta.

South of town between Henrietta and Jacksboro, students attend Midway Independent School District.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.