Henrietta Williams Settle Reid (October 7, 1824 – March 3, 1913) was an American planter who, as the wife of David Settle Reid, was the first lady of North Carolina from 1851 to 1854.

[1] She was the daughter of U.S. congressman Thomas Settle Sr. and Henrietta Williams Graves.

[3] She married her first cousin, David Settle Reid, on December 19, 1850.

[4] They lived at the 700-acre Reid Plantation near the Dan River, where they enslaved twenty-two people.

[1][3] Reid died from pneumonia on March 3, 1913 in Reidsville, North Carolina.