Henriette Simon Picker (28 March 1917 – 5 January 2016) was an American painter, fashion designer, and inventor.

After fleeing Germany following the rise of Hitler, the family resettled in New York, where Picker studied drawing and painting with Alexander Brook and Louis Bouché at the Art Students League of New York while pursuing a career as a shoe designer.

At the age of sixteen, she became the first woman designer hired by I. Miller, a shoe company.

[8][9] Picker's final years were almost entirely focused upon portraiture, including Ruth Bader Ginsburg, Mikael Karlsson (composer), Richard Croft (tenor), Ida Rohatyn, and Charles Wuorinen.

A book chronicling her work entitled Henriette Simon Picker: A Century of Painting was published posthumously.