Henry Detweiler Heller (1850-1928) was an American politician who served as a Republican in the Pennsylvania State Senate for one term from 1895 to 1898 representing Northampton County in the 18th district.

He attended Claverack College for his undergraduate and studied medicine at the Bellevue Hospital Medical College, now the New York University Grossman School of Medicine, graduating in 1871.

He was elected to the state senate in 1895 as a Republican, and would hold office until 1898.

Afterwards he was named the State Quarantine Physician by Governor William A.

He was a shareholder of the Thomas Iron Company and owned a limestone quarry.