At the time of his father's will, Henry Hele had two brothers, Richard (1688/89–1756), later a prebendary of Salisbury) and John, and two sisters, Amy and Susannah.
He engaged in a long-running professional controversy in the Salisbury Journal with his younger rival, John Barker (1708–1749).
Towards the end of his long life, in 1776, he became involved in a scandal concerning an alleged conspiracy by one Mary Bowes to have her sister Diana forcibly incarcerated in a lunatic asylum; Hele signed the certificate of lunacy that made the scheme possible and was indicted by a grand jury.
[3] He was involved in numerous land transactions and acquired, in particular, the manors of Sock Dennis[4] and South Petherton in Somerset, and Brook House and Lodgwood Farm, near Westbury, Wiltshire.
[Memoriae sacrum] Henrici Hele qui rem medicam in hoc clause & civitate adjacenti per quinqueginta annose probe & feliciter exercuit".