Henry Joseph Clarke (July 7, 1833 – September 13, 1889), who sometimes used the middle names Hynes and O'Connell, was a lawyer and politician in Manitoba, Canada.

He practiced law in Montreal, Lower Canada, before moving to California during the "gold rush" of 1858, and also lived in El Salvador for a period in the early 1860s.

Clarke ran for Province of Canada's parliament as a Liberal-Conservative in the 1863 election, losing to Liberal finance minister Luther Hamilton Holton in the riding of Chateauguay.

In 1871, he navigated a bill through the assembly which would have restricted the number of out-of-province lawyers to ten, and given the Attorney General's office final authority over who could practice.

As such, he was opposed by both "ultra-loyalists" among the English and by Riel's more numerous supporters among the Métis, and frequently clashed with fellow cabinet member Joseph Royal, a political spokesman for the latter group.

When three Métis were arrested on charges of treason following Fenian raids in 1871, Clarke personally led the prosecution while Royal acted at the chief defense lawyer.

Like his "predecessors" Alfred Boyd and Marc-Amable Girard, Clarke was simply a leading minister in a cabinet controlled by the province's Lieutenant Governors.