During his time at the school, he was classmates with many successful people, among who were Dr. Dharmasena Attygalle, Karunaratne Abeysekera, Dr. Harischandra Wijayatunga, Dr. Hudson Silva, Hon.
[10] Prior to acting, Jayasena began his career as an assistant teacher of English at the Dehipe Primary School in Padiyapellela in the Nuwara Eliya district in 1950.
However, Jaysena left this post a few months later after passing the General Clerical Service Examination and securing a job with the Public Works Department (PWD) of Sri Lanka.
[9] While with Public Works Department, Jaysena created many of his most famous plays, including Pawkarayo [12] (1958), Janelaya (1962), Kuweni (1963), Thavath Udesenak (1964), Manaranjana Wedawarjana (1965), Ahas Malilga (1966), Hunuwataye Kathawa (1967), Apata Puthey Magak Nethey (1968), Diriya Mawa (1972), Makara (1973) and Sarana Siyoth Se Puthini Habha Yana (1975).
He portrayed the role of "Sudu Seeya" in the tele drama Doo Daruwo directed by Nalan Mendis and written by Dr. Somaweera Senanayaka.