[1] Morley graduated in 1843 and became part of the Worshipful Society of Apothecaries, a professional organization, that same year.
Morley worked as a physician in partnership with another doctor in Madeley, Shropshire, but it turned into a financial failure because of the dishonesty of his partner who was unlicensed.
Morley wrote some satirical articles that were published and gained the attention of Charles Dickens.
From 1865 to 1889, Morley served as Professor of English Literature at University College London, his students including the Indian writer Rabindranath Tagore.
[2] He supported in particular Annie Leigh Browne when she opened in 1882 a residence for women students at Byng Place, renamed College Hall in 1886.
Morley was the author of biographies on Bernard Palissy, Heinrich Cornelius Agrippa, Gerolamo Cardano and Clément Marot.