Henry O'Brien, 7th Earl of Thomond PC (Ire) (c. 1620 – 2 May 1691) was an Irish peer and Chief of Clan O'Brien.
O'Brien was the son of Barnabas O'Brien, 6th Earl of Thomond and Anne Fermor.
In 1641, he married his first cousin Anne O'Brien (d. September 1645), daughter of Henry O'Brien, 5th Earl of Thomond, by whom he had one son: After Anne's death, he married Sarah Russell, daughter of Sir Francis Russell, and widow of Sir John Reynolds.
This made O'Brian a brother-in-law of Henry Cromwell, who had married Sarah's sister Elizabeth.
[1] O'Brian and Sarah had five children: This biography of an earl in the Peerage of Ireland is a stub.