Sir Henry Seton-Karr CMG DL (5 February 1853 – 29 May 1914) was an English explorer, hunter and author and a Conservative politician who sat in the House of Commons from 1885 to 1906.

Seton-Karr, born in India in 1853, was the son of George Berkeley Seton-Karr, of the Indian Civil Service (resident Commissioner at Baroda during the Indian Mutiny);[1] and his wife Eleanor, the daughter of Henry Usborne of Branches Park, Suffolk.

He was educated at Harrow School and Corpus Christi College, University of Oxford gaining an MA in law in 1876.

At Grange Park Golf Club, St Helens an annual competition is still played in the name of Seton-Karr.

Seton-Karr died in the sinking of the RMS Empress of Ireland on the Saint Lawrence River, the worst maritime disaster in Canadian history; he was returning to England from a hunting trip in British Columbia.