Henry Smith Holden CBE FRSE FLS (30 November 1887 – 16 May 1963) was a British botanist.
His father died during his university course, and Henry took over the role of maintaining his mother and the cost of educating his younger brother, Ernest Holden, as soon as he was able.
His career was interrupted by the First World War, during which he served (1916–19) as a bacteriologist at the Royal Naval Hospital in Portsmouth.
His proposers were Sir William Wright Smith, Robert Graham, Malcolm Wilson, James Montagu Frank Drummond, and James Robert Matthews.
After some earlier police consultation on issues relating to water pollution and food contamination, he was asked by the Home Office to set up Britain’s first forensic laboratory in Nottingham in 1936, serving all of England and Wales.