Henry Tefft Clarke Sr. (April 26, 1834 – February 3, 1913) was an American businessman, pioneer, and politician from Nebraska.
Born in Greenwich, New York, he was educated in the local schools.
He moved to Cleveland, Ohio and eventually to Nebraska Territory, where he built railroads and bridges.
Eventually, he opened a retail drug company and helped platted Bellevue, Nebraska.
He also served on the Omaha, Nebraska Board of Education also during this time.