[6] Elementary schools feeding into Midtown High are: Centennial Place, Mary Lin, Hope-Hill, Morningside, and Springdale Park.

The "Henry W. Grady Senior High School for Boys" moved to the current campus site in 1924.

From 2011 to 2015, Grady was home to four small learning communities: Communications and Journalism, Public Policy and Justice, Business and Entrepreneurship, and Biomedical Science and Engineering.

In fall 2021, the school opened with a $34.9 million renovation funded by the one-penny Education Special Purpose Local Option Sales Tax (E-SPLOST).

[3] Designed by Cooper Carry, this encompassed a 339,192 square foot renovation and 63,063 square foot four-level addition with ten classrooms (to replace modular ones), four industry-certified career, technical and agricultural education spaces, two science labs, a media center, administrative offices and counseling spaces.

[2] Improvements to the existing buildings include a larger cafeteria with a school store, and a family living center for students with special needs to learn life skills.

[10] On December 15, 2020, the Board officially announced the name change to Midtown High School effective June 1, 2021.

The library retains copies of every book and the yearbook is primarily created in one of the school's publication classes in the journalism track offered to students.

Grady News Now and Gametime were Midtown High School's programs in broadcast journalism, and are also recipients of many awards.

Gametime is a weekly show dedicated to the coverage of prevalent sports stories as well as scores and highlights from all scholastic athletic events.