Sir Henry Wentworth of Nettlestead, Suffolk, KB (born c. 1448, died between 17 August 1499 and 27 February 1501), de jure 4th Baron le Despenser was an English baron who is notable for being the grandfather of Henry VIII's third wife, Jane Seymour, and the great-grandfather of Jane's son, Edward VI.

Henry Wentworth, born about 1448, was the only son and heir of the courtier Sir Philip Wentworth (d. 18 May 1464) of Nettlestead, Suffolk, beheaded after the Battle of Hexham, and Mary Clifford, daughter of John Clifford, 7th Baron de Clifford, by Lady Elizabeth Percy, the daughter of Henry Percy.

In taking as her second husband Roger Wentworth, a younger son of John Wentworth of North Elmsall, Yorkshire, Sir Philip's mother, Margery, Lady Roos, who was the daughter and heiress of Philip le Despenser, 2nd Baron le Despenser, was said to have "married herself dishonourably without licence from the King".

[2][3] Sir Philip Wentworth served in the army of King Henry VI in the Wars of the Roses.

[4] Wentworth married, firstly, Anne Say (died before 22 October 1494) on about 25 February 1470, the daughter of Sir John Say and Elizabeth Cheyney, by whom he had two sons and four daughters:[4][5][6][7] Wentworth married, secondly, by licence dated 22 October 1494, Elizabeth Neville (d. September 1517), widow of Thomas Scrope, 6th Baron Scrope of Masham and Upsall (d. 23 April 1493), and second daughter of John Neville, 1st Marquess of Montagu by Isabel, daughter of Sir Edmund Ingaldsthorpe, by whom he had no issue.