Henry of Lorraine, Duke of Mayenne

Henry of Mayenne or Henry of Lorraine, (Dijon, 20 December 1578 – Montauban, 20 September 1621) was a French noble from the House of Lorraine and more particularly from the House of Guise.

He was the eldest son of Charles, Duke of Mayenne and Henriette of Savoy, Marquise of Villars.

He also became a peer of France and inherited the Hôtel de Mayenne in Paris.

He was present at the coronation of King Louis XIII of France.

In 1621, he was killed at the failed Siege of Montauban by a musket shot in the eye.