Hensen's cells are currently being investigated to be promising targets for gene therapy and regenerative medicine.

[4] Hensen's cells have rigid cytoskeletons which are responsible to maintain the structure of the organ of Corti during sound exposure.

The gap junctions play an important role in regulating the concentration of intracellular K+ between the endolymph and the perilymph, maintaining pH homeostasis, and increasing movement of the ions between cells.

[4][5] The mutations in connexin 26, which is an important gap junction protein found in the organ of Corti, would results in severe hearing loss and is one of the most common inherited nonsyndromic deafness.

[4] The terminals, on the other hand, are more common in the basal of the cochlea, and contain mitochondria, Golgi apparatus and dense core vesicles.

[9] The innervation of the supporting cells were shown by the finding of synaptophysin-immunostained terminals in the guinea pigs and rats.

[10] There are increased evidence indicating that supporting cells serve many critical functions within the Organ of Corti, they may mediate the initiation of hearing activate during cochlea development.

[6] The outer hair cells of the cochlea preprocess the signal by active movements, which can be elevated by electrical or chemical stimulation.

[4] When ATP induced an increase in cytoplasmic calcium, membrane becomes depolarized and the outer hair cells are contracted.

[2] After the noise exposure, the ATP levels elevated and change the K+ conductance through the P2X receptors by reducing the endo cochlear potential (EP).

As a result, the purinergic signaling mechanism act as a regulation of homeostasis which decrease the cochlear sensitivity to noise exposure, loss function of the purinergic receptors expressed in the Hensen's cells in the cochlea may lead to noise-induced hearing loss (NIHL).

The ionized calcium plays a critical role in many functions, such as cell proliferation, differentiation, and cell apoptosis, there are several factors that cause the increased concentration in the cochlea, including continuous exposure to noise which lead to overstimulation, thus maintaining homeostasis of the Ca2+ concentration is important.