[5] Viruses in the genus Hepacivirus are enveloped and have spherical icosahedral-like geometries with pseudo T=3 symmetry.

[3][4] In the genus Hepacvirus there are 14 species:[7][3] Additional hepaciviruses have been described from bats, rodents including bank voles, horses, and dogs.

[5] A virus related to hepaciviruses is found in bamboo rat (Rhizomys pruinosus).

[11] A virus related to hepaciviruses infects the long-tailed ground squirrel Spermophilus undulatus.

[17] A virus related to the hepaciviruses has been isolated from bald eagles (Haliaeetus leucocephalus).

[19] A virus related to hepaciviruses has been isolated from the graceful catshark (Proscyllium habereri).