[1] The patient may experience many symptoms, including weight loss, poor appetite, and lethargy; jaundice and bruising may also be present.

[15] Suspicion of hepatomegaly indicates a thorough medical history and physical examination, wherein the latter typically includes an increased liver span.

[citation needed] On abdominal ultrasonography, the liver can be measured by the maximum dimension on a sagittal plane view through the midclavicular line, which is normally up to 18 cm in adults.

[medical citation needed] A complete blood test can help distinguish intrinsic liver disease from extrahepatic bile-duct obstruction.

[23] In primary biliary cirrhosis, ursodeoxycholic acid helps the bloodstream remove bile, which may increase survival.