Hepatotoxin

It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).

The effects of hepatotoxins depend on the amount, point of entry and distribution speed of the [toxin], and on the health of the person.

Idiosyncratic (type B) hepatotoxic reactions are unpredictable, independent of dose, and appear to be determined by the individual exposed.

Compounds that preferentially affect bile ducts are referred to as "cholestatic", one example being chlorpromazine.

"Mixed" toxicity, affecting both the bile ducts and hepatocytes, is not uncommon.