Caldoramide is a pentapeptide[1] isolated from the cyanobacteria Caldora penicillata.

[2] It has cytotoxic effects on cancer cells and has been the subject of extensive oncological research.

[3] Freeze-dried samples of Caldora penicillata had EtOAc−MeOH and H2O−EtOH applied to them in order to extract Caldoramide.

The extracts were partitioned with n-BuOH and H2O and then fractions were taken based on solubility in either EtOAc or BuOH.

[3] Caldoramide has been found to be cytotoxic against HCT116 colorectal cancer cell lines.