Hephaestion, Hephaistion, or Hephaistio of Thebes (Ancient Greek: Ἡφαιστίων ὁ Θηβαῖος, Hēphaistíōn ho Thēbaĩos) was a Hellenized Egyptian astrologer of late Antiquity who wrote a Greek treatise known as the Apotelesmatics or Apotelesmatika around AD 415.
Hephaestion is seen mainly as one of the later compilers of the Hellenistic tradition of astrology since he mainly draws from earlier astrologers, including Antiochus of Athens, and he summarizes large portions of Ptolemy and Dorotheus, which is helpful to modern scholars since we have no other record of many of the authorities that he quotes.
Hephaestion's intention appears to have been to reconcile the authoritative Ptolemaic tradition with the earlier practices represented by Dorotheus of Sidon.
He wrote at a time and in a place (possibly Alexandria) when astrological ideas were being summarized and consolidated, after the removal of the capital of the Empire from Rome to Constantinople.
Although influential on later Byzantine astrologers, his work seems to have had little impact in the Arab tradition which followed.