If so, wouldn't that be amazing!The studio album features female singers including Cyndi Lauper, Tori Amos, Martha Wainwright, Natalie Merchant, Sia, Santigold, Charmaine Clamor, Nicole Atkins, Sharon Jones, St. Vincent, Kate Pierson, Florence Welch, Allison Moorer, and Nellie McKay, alternately playing the roles of Imelda Marcos and Estrella Cumpas.

The only male vocalists are Steve Earle on "A Perfect Hand", and Byrne himself on "American Troglodyte" and "Seven Years", the latter a duet with Shara Nova from My Brightest Diamond.

It was first presented as a song cycle (with vocals by Byrne, Dana Diaz-Tutaan and Ganda Suthivarakom) at the Adelaide Festival of Arts under the artistic direction of Brett Sheehy in Adelaide, Australia, on 10 March 2006 with additional dates on 13 and 14 March, and was also performed live at the Carnegie Hall in New York City on 3 February 2007, as part of the Carnegie Hall Perspectives Series.

[20] The album was adapted into a stage musical, directed by Alex Timbers, that premiered off-Broadway at The Public Theater in New York City in 2013.

[32] The musical started previews on Broadway on 17 June 2023 and opened officially on 20 July 2023, produced by Hal Luftig, Patrick Catullo, Diana DiMenna, Clint Ramos and Jose Antonio Vargas.

It recreated the immersive experience with a mostly standing-room format which, according to the producers, "transform[s] the venue’s traditional proscenium floor space into a dance club environment, where audiences ... stand and move with the actors".