[4] Pressure on the nerves can cause tingling sensations, numbness, pain, weakness, muscle atrophy and even paralysis of the affected area.

HNPP is part of the group of hereditary motor and sensory neuropathy (HMSN) disorders and is linked to Charcot–Marie–Tooth disease (CMT).

HNPP has not been found to alter the lifespan, although in some cases a decline in quality of life is noticed.

There is a wide range in the severity of these symptoms[6] HNPP is typically caused by autosomal dominant deletion of PMP22 (peripheral myelin protein 22 at locus 17p11.2).

[11] It is involved in maintaining the myelin sheath that surrounds peripheral nerves to facilitate conductivity.

Dyck and Lambert (1968) showed nerve conduction studies, and Chance et al. (1993) detected the chromosome deletion in most of the individuals with the HNPP condition.