Here, SR 388 is known as Wrightsboro Road, a major urban corridor farther to the east in Augusta.

SR 223 north of here is also known as Wrightsboro Road, but is known as West Robinson Avenue southeast of here.

Here, SR 388 turns left onto Horizon South Parkway, while Wrightsboro Road continues to the east toward Augusta.

It leaves the city limits of Grovetown just before passing a campus of Augusta Technical College and crossing over Mill Branch.

A short distance later, it curves to the north-northwest and has a brand new diverging diamond interchange with Interstate 20 (I-20; Carl Sanders Highway) and its internal designation of SR 402, which was converted from a formerly diamond interchange and was opened at February 26, 2024.

Here, the roadway crosses over the Interstate highway on the Lieutenant General James E. Gray Memorial Bridge and becomes known as Lewiston Road.

At an intersection with the eastern terminus of Mill Creek Lane, it curves back to the north-northwest.

SR 388 will also have a diverging diamond interchange with I-20 in the future, which was completed and opened at February 26, 2024.

[15] The highway begins at an intersection with US 221/SR 47 (North Louisville Street) in Harlem and travels to the east-northeast.

A short distance later, it leaves the city limits of Harlem and then crosses over Euchee Creek.

In Grovetown, it passes the Grovetown Trails at Euchee Creek, Grovetown Middle School, and Cedar Ridge Elementary School, just before meeting its eastern terminus, an intersection with SR 223 (known as Wrightsboro Road northwest of the intersection and West Robinson Avenue southeast of it) and the southern terminus of SR 388 (Wrightsboro Road).

Just after crossing over Tudor Branch, the highway begins skirting the northwestern edge of the city limits of Evans.

Towne Centre Drive is the name for what is essentially an eastern extension of Hereford Farm Road.

It passes the Evans campus of University Hospital and then curves to the east-northeast before meeting its northern terminus, an intersection with SR 104 (Washington Road).